Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/908
Título: Zero-Time Kidney Histology Predicts Early Graft Function
Autor: Viana, H
Carvalho, F
Galvão, MJ
Santos, A
Nolasco, F
Palavras-chave: Transplantação de Rim
Biópsia
Histologia
Data: 2010
Editora: Laboratório de Morfologia Renal e Unidade de Transplantação de Rim do Hospital Curry Cabral
Citação: IN: Renal Week 2010: American Society of Nephrology 43rd Annual Meeting, 2010, 16 a 21 Nov. Denver, Colorado, EUA
Resumo: Our purposes are to determine the impact of histological factors observed in zero-time biopsies on early post transplant kidney allograft function. We specifically want to compare the semi-quantitative Banff Classification of zero time biopsies with quantification of % cortical area fibrosis. Sixty three zero-time deceased donor allograft biopsies were retrospectively semiquantitatively scored using Banff classification. By adding the individual chronic parameters a Banff Chronic Sum (BCS) Score was generated. Percentage of cortical area Picro Sirius Red (%PSR) staining was assessed and calculated with a computer program. A negative linear regression between %PSR/ GFR at 3 year post-transplantation was established (Y=62.08 +-4.6412X; p=0.022). A significant negative correlation between arteriolar hyalinosis (rho=-0.375; p=0.005), chronic interstitial (rho=0.296; p=0.02) , chronic tubular ( rho=0.276; p=0.04) , chronic vascular (rho= -0.360;P=0.007), BCS (rho=-0.413; p=0.002) and GFR at 3 years were found. However, no correlation was found between % PSR, Ci, Ct or BCS. In multivariate linear regression the negative predictive factors of 3 years GFR were: BCS in histological model; donor kidney age, recipient age and black race in clinical model. The BCS seems a good and easy to perform tool, available to every pathologist, with significant predictive short-term value. The %PSR predicts short term kidney function in univariate study and involves extra-routine and expensive-time work. We think that %PSR must be regarded as a research instrument.
Peer review: yes
URI: http://hdl.handle.net/10400.17/908
Aparece nas colecções:NEF - Comunicações e Conferências

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