Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/531
Título: Head-Up Tilt Testing with Different Nitroglycerin Dosages: Experience in Elderly Patients with Unexplained Syncope
Autor: Timóteo, AT
Oliveira, MM
Feliciano, J
Antunes, E
Nogueira da Silva, M
Silva, S
Santos, S
Cruz Ferreira, R
Palavras-chave: Relação Dose-Resposta a Medicamento
Inclinação da Cabeça
Replicação de Resultados
Sensibilidade e Especificidade
Data: 2008
Editora: European Society of Cardiology
Citação: Europace. 2008 Sep;10(9):1091-4
Resumo: AIMS: Protocols using sublingual nitrates have been increasingly used to improve diagnostic accuracy of head-up tilt testing (HUT). Nevertheless, exaggerated responses to nitrates have been frequently described, particularly in elderly patients. The aim of this article is to evaluate, in an elderly population with unexplained syncope, whether the impact of sublingual nitroglycerin (NTG) used as a provocative agent is dose-dependent. METHODS AND RESULTS: One hundred and twenty consecutive elderly patients submitted to HUT using NTG after an asymptomatic drug-free phase were studied. Patients were divided into three groups according to the NTG dosage: 500, 375 and 250 microg. The test was considered positive when there was reproduction of symptoms with bradycardia and/or arterial hypotension. A gradual decrease in the blood pressure after NTG was considered an exaggerated response to nitrates. There were no differences in the clinical characteristics of the different subgroups. A positive test was obtained in 50% of the patients in each group. The rate of exaggerated responses was identical in all groups and ranged between 15 and 17%. CONCLUSION: In an elderly population with syncope of unknown origin submitted to HUT, the response to NTG is not dose-dependent, and no difference was found in the rate of exaggerated responses to nitrates with different NTG dosages.
Peer review: yes
URI: http://hdl.handle.net/10400.17/531
Aparece nas colecções:CAR - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Europace 2008 1091.pdf66,74 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.