Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2973
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dc.contributor.authorGarzón, M-
dc.contributor.authorPereira-da-Silva, L-
dc.contributor.authorSeixas, J-
dc.contributor.authorPapoila, AL-
dc.contributor.authorAlves, M-
dc.contributor.authorFerreira, F-
dc.contributor.authorReis, A-
dc.date.accessioned2018-05-10T12:00:44Z-
dc.date.available2018-05-10T12:00:44Z-
dc.date.issued2017-05-
dc.identifier.citationPathog Glob Health. 2017 May;111(3):116-127pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2973-
dc.description.abstractThe cumulative effect of repeated asymptomatic enteric infections on intestinal barrier is not fully understood in infants. We aimed to evaluate the association between previous enteric parasitic infections and intestinal inflammation and permeability at 24-months of age, in asymptomatic infants of São Tomé Island. A subset of infants from a birth cohort, with intestinal parasite evaluations in at least four points of assessment, was eligible. Intestinal inflammatory response and permeability were assessed using fecal S100A12 and alpha-1-antitrypsin (A1AT), respectively. The cutoff <-1SD for weight-for-length and length-for-age was used to define wasting and stunting. Multivariable linear regression analysis explored if cumulative enteric parasitic infections explained variability of fecal biomarkers, after adjusting for potential confounders. Eighty infants were included. Giardia duodenalis and soil-transmitted helminths (STH) were the most frequent parasites. The median (interquartile range) levels were 2.87 μg/g (2.41-3.92) for S100A12 and 165.1 μg/g (66.0-275.6) for A1AT. Weak evidence of association was found between S100A12 levels and G. duodenalis (p = 0.080) and STH infections (p = 0.089), and between A1AT levels and parasitic infection of any etiology (p = 0.089), at 24-months of age. Significant associations between A1AT levels and wasting (p = 0.006) and stunting (p = 0.044) were found. Previous parasitic infections were not associated with fecal biomarkers at 24 months of age. To summarize, previous asymptomatic parasitic infections showed no association with intestinal barrier dysfunction. Notwithstanding, a tendency toward increased levels of the inflammatory biomarker was observed for current G. duodenalis and STH infections, and increased levels of the permeability biomarker were significantly associated with stunting and wasting.pt_PT
dc.language.isoengpt_PT
dc.publisherTaylor & Francispt_PT
dc.rightsopenAccesspt_PT
dc.subjectAnimalspt_PT
dc.subjectBody Weightpt_PT
dc.subjectFecespt_PT
dc.subjectFemalept_PT
dc.subjectGiardia lambliapt_PT
dc.subjectGiardiasispt_PT
dc.subjectHelminthiasispt_PT
dc.subjectHelminthspt_PT
dc.subjectHumanspt_PT
dc.subjectInfantpt_PT
dc.subjectInflammationpt_PT
dc.subjectIntestinal Diseases, Parasiticpt_PT
dc.subjectMalept_PT
dc.subjectPermeabilitypt_PT
dc.subjectSao Tome and Principept_PT
dc.subjectSoilpt_PT
dc.subjectHDE CINVpt_PT
dc.titleAssociation of Enteric Parasitic Infections with Intestinal Inflammation and Permeability in Asymptomatic Infants of São Tomé Islandpt_PT
dc.typearticlept_PT
dc.peerreviewedyespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage116pt_PT
degois.publication.lastPage127pt_PT
degois.publication.issue3pt_PT
degois.publication.volume111pt_PT
dc.identifier.doi10.1080/20477724.2017.1299831pt_PT
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