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Title: Cutaneous Leukemic Infiltration Following Varicella - a Case of Wolf's Isotopic Response
Author: Brasileiro, A
Lencastre, A
João, A
Fidalgo, A
Keywords: Chickenpox
Herpes Zoster
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemic Infiltration
Middle Aged
Skin Diseases, Viral
Treatment Outcome
Issue Date: 2016
Publisher: Sociedade Brasileira de Dermatologia
Citation: An Bras Dermatol. 2016 Sep-Oct;91(5 suppl 1):72-75.
Abstract: Wolf's isotopic response designates the appearance of two subsequent unrelated dermatoses in the same anatomic location. We report the case of a 51-year-old man with a medical history of chronic lymphocytic leukemia without known extra-hematopoietic involvement. The patient developed a disseminated papulo-vesiculous eruption, diagnosed as varicella. Few days after recovering, an erythematous and violaceous papular dermatosis with histopathological examination compatible with leukemic infiltration appeared on the scars of previous herpetic lesions. Complete remission was obtained under systemic corticotherapy, without cutaneous recurrence or blastic transformation. Wolf's isotopic response is attributed to a localized immunologic imbalance following a certain stimulus. In this patient, herpetic infection acted as a local spur for inaugural cutaneous leukemic infiltration, with no impact on the prognosis for the underlying disease.
Peer review: yes
DOI: 10.1590/abd1806-4841.20164686
Appears in Collections:DER - Artigos

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