Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2846
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dc.contributor.authorRodrigues, I-
dc.contributor.authorAgapito, A-
dc.contributor.authorSousa, L-
dc.contributor.authorOliveira, JA-
dc.contributor.authorBranco, LM-
dc.contributor.authorGalrinho, A-
dc.contributor.authorAbreu, J-
dc.contributor.authorTimóteo, AT-
dc.contributor.authorAguiar Rosa, S-
dc.contributor.authorCruz Ferreira, R-
dc.date.accessioned2018-01-12T14:12:22Z-
dc.date.available2018-01-12T14:12:22Z-
dc.date.issued2017-04-
dc.identifier.citationCardiol Young. 2017 Apr;27(3):518-529.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2846-
dc.description.abstractBACKGROUND: Bicuspid aortic valve is the most common CHD. Its association with early valvular dysfunction, endocarditis, thoracic aorta dilatation, and aortic dissection is well established. OBJECTIVE: The aim of this study was to assess the incidence and predictors of cardiac events in adults with bicuspid aortic valve. METHODS: We carried out a retrospective analysis of cardiac outcomes in ambulatory adults with bicuspid aortic valve followed-up in a tertiary hospital centre. Outcomes were defined as follows: interventional - intervention on the aortic valve or thoracic aorta; medical - death, aortic dissection, aortic valve endocarditis, congestive heart failure, arrhythmias, or ischaemic heart disease requiring hospital admission; and a composite end point of both. Kaplan-Meier curves were generated to determine event rates, and predictors of cardiac events were determined by multivariate analysis. RESULTS: A total of 227 patients were followed-up over 13±9 years; 29% of patients developed severe aortic valve dysfunction and 12.3% reached ascending thoracic aorta dimensions above 45 mm. At least one cardiac outcome occurred in 38.8% of patients, with an incidence rate at 20 years of follow-up of 47±4%; 33% of patients were submitted to an aortic valve or thoracic aorta intervention. Survival 20 years after diagnosis was 94±2%. Independent predictors of the composite end point were baseline moderate-severe aortic valve dysfunction (hazard ratio, 3.19; 95% confidence interval, 1.35-7.54; p<0.01) and aortic valve leaflets calcification (hazard ratio, 4.72; 95% confidence interval, 1.91-11.64; p<0.005). CONCLUSIONS: In this study of bicuspid aortic valve, the long-term survival was excellent but with occurrence of frequent cardiovascular events. Baseline aortic valve calcification and dysfunction were the only independent predictors of events.pt_PT
dc.language.isoengpt_PT
dc.publisherCambridge University Presspt_PT
dc.rightsopenAccesspt_PT
dc.subjectAdultpt_PT
dc.subjectAortic Aneurysm, Thoracicpt_PT
dc.subjectAortic Valvept_PT
dc.subjectAortic Valve Insufficiencypt_PT
dc.subjectAortic Valve Stenosispt_PT
dc.subjectCause of Deathpt_PT
dc.subjectDisease Progressionpt_PT
dc.subjectEchocardiography, Dopplerpt_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectHeart Valve Diseasespt_PT
dc.subjectHumanspt_PT
dc.subjectIncidencept_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectOutpatientspt_PT
dc.subjectPrognosispt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectSurvival Ratept_PT
dc.subjectUnited Statespt_PT
dc.subjectYoung Adultpt_PT
dc.subjectForecastingpt_PT
dc.subjectHSM CARpt_PT
dc.titleBicuspid Aortic Valve Outcomespt_PT
dc.typearticlept_PT
dc.peerreviewedyespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage518pt_PT
degois.publication.lastPage529pt_PT
degois.publication.issue3pt_PT
degois.publication.titleCardiology in the Youngpt_PT
degois.publication.volume27pt_PT
dc.identifier.doi10.1017/S1047951116002560pt_PT
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