Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2842
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dc.contributor.authorPinto, MF-
dc.contributor.authorGomes, I-
dc.contributor.authorLoureiro, P-
dc.contributor.authorLaranjo, S-
dc.contributor.authorTimóteo, AT-
dc.contributor.authorMota Carmo, M-
dc.date.accessioned2018-01-09T16:34:12Z-
dc.date.available2018-01-09T16:34:12Z-
dc.date.issued2017-04-
dc.identifier.citationCardiol Young. 2017 Apr;27(3):488-497pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2842-
dc.description.abstractBACKGROUND: Kawasaki disease is an acute systemic vasculitis. Cardiac complications are frequent and include endothelial dysfunction in patients with coronary anomalies. Thus far, endothelial dysfunction in patients with no coronary lesions is poorly understood. Our aim was to access the vascular function in adolescents and young adults long term after Kawasaki disease, but without coronary aneurysms or any other cardiac risk factors. METHODS: We carried out a single-centre prospective study in a Portuguese population. We evaluated two groups of subjects: (1) Kawasaki disease patients over 11 years of age, diagnosed >5 years ago, with no coronary lesions or any other risk factors for cardiovascular disease; (2) control group of individuals without cardiovascular risk factors. Patients and controls were clinically assessed. Endo-PAT and carotid intima-media thickness assessment were performed to determine vascular function. RESULTS: In total, 43 Kawasaki disease patients were assessed and compared with 43 controls. Kawasaki disease patients presented a decreased reactive hyperaemia index compared with controls (1.59±0.45 versus 1.98±0.41; p<0.001). Augmentation index was similar in both groups (-4.5±7 versus -5±9%; p 0.6). The mean carotid intima-media thickness was not significantly increased in the Kawasaki disease group. There were no statistically significant changes with regard to laboratory data. CONCLUSIONS: Children with Kawasaki disease may have long-term sequelae, even when there is no discernible coronary artery involvement in the acute stage of the disease. Further research is needed to assess whether known strategies to improve endothelial function would bring potential benefits to Kawasaki disease patients.pt_PT
dc.language.isoengpt_PT
dc.publisherCambridge University Presspt_PT
dc.rightsopenAccesspt_PT
dc.subjectAdolescentpt_PT
dc.subjectCarotid Arteriespt_PT
dc.subjectCarotid Intima-Media Thicknesspt_PT
dc.subjectChildpt_PT
dc.subjectEndothelium, Vascularpt_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMucocutaneous Lymph Node Syndromept_PT
dc.subjectProspective Studiespt_PT
dc.subjectRisk Factorspt_PT
dc.subjectTime Factorspt_PT
dc.subjectVascular Stiffnesspt_PT
dc.subjectYoung Adultpt_PT
dc.subjectHSM CAR PEDpt_PT
dc.subjectHSM CARpt_PT
dc.titleVascular Function Long Term After Kawasaki Disease: Another Piece of the Puzzle?pt_PT
dc.typearticlept_PT
dc.peerreviewedyespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage488pt_PT
degois.publication.lastPage497pt_PT
degois.publication.issue3pt_PT
degois.publication.titleCardiology in the Youngpt_PT
degois.publication.volume27pt_PT
dc.identifier.doi10.1017/S1047951116000780pt_PT
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CAR PED - Artigos

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