Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2674
Título: Apolipoprotein E Polymorphism Interacts with Cigarette Smoking in Progression of Multiple Sclerosis
Autor: Sena, A
Couderc, R
Ferret-Sena, V
Pedrosa, R
Andrade, ML
Araujo, C
Roque, R
Cascais, MJ
Morais, MG
Palavras-chave: Adult
Apolipoproteins E
Disability Evaluation
Disease Progression
Middle Aged
Multiple Sclerosis
Polymorphism, Genetic
Severity of Illness Index
Genetic Predisposition to Disease
Data: Jul-2009
Editora: Wiley
Citação: Eur J Neurol. 2009 Jul;16(7):832-7
Resumo: BACKGROUND AND PURPOSE: The influence of apolipoprotein E (ApoE) polymorphism on clinical severity of multiple sclerosis (MS) is still controversial. Cigarette smoking has been suggested to influence the progression of disability in these patients. In this study, we aimed to investigate whether an interaction of smoking with the ApoE polymorphism influences the progression of disability in MS patients. METHODS: Smoking history from 205 female patients with MS was obtained. Clinical data collected include age at onset, disease duration, annual relapse rate, the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Severity Score (MSSS). ApoE polymorphism was examined in all patients and stratified according to smoking status and associations with the clinical data investigated. RESULTS: There were no significant associations between cigarette smoking and any of the clinical characteristics in the whole group of patients. In women carrying the ApoE E4 isoform, smokers had a lower EDSS (P = 0.033) and MSSS (P = 0.023) in comparison with non-smokers. CONCLUSION: Our data suggest that in women with MS carrying the ApoE E4 isoform, cigarette smoking may have a protective influence on disease progression and accumulation of disability. These findings need to be confirmed by future large longitudinal studies.
Peer review: yes
URI: http://hdl.handle.net/10400.17/2674
DOI: 10.1111/j.1468-1331.2009.02603.x
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