Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2672
Título: Does Admission NT-ProBNP Increase the Prognostic Accuracy of GRACE Risk Score in the Prediction of Short-Term Mortality After Acute Coronary Syndromes?
Autor: Timóteo, AT
Toste, A
Ramos, R
Miranda, F
Ferreira, ML
Oliveira, JA
Cruz Ferreira, R
Palavras-chave: Analysis of Variance
Biomarkers
Chi-Square Distribution
Female
Humans
Linear Models
Logistic Models
Male
Middle Aged
Multivariate Analysis
Natriuretic Peptide, Brain
Peptide Fragments
Portugal
Predictive Value of Tests
Prognosis
ROC Curve
Retrospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Statistics, Nonparametric
Ventricular Dysfunction, Left
Acute Coronary Syndrome
Hospital Mortality
Patient Admission
HSM CAR
HSM PAT CLIN
Data: 2009
Editora: Informa Healthcare
Citação: Acute Card Care. 2009;11(4):236-42
Resumo: BACKGROUND: NT-proBNP has prognostic implications in heart failure. In acute coronary syndromes (ACS) setting, the prognostic significance of NT-proBNP is being sought. We studied short-term prognostic impact of admission NT-proBNP in patients admitted for ACS and in association with GRACE risk score (GRS). METHODS AND RESULTS: We studied 1035 patients admitted with ACS. Patients were divided in quartiles according to NT-proBNP levels on admission: Q1 <180 pg/ml; Q2 180-691 pg/ml; Q3 696-2664 pg/ml; Q4 2698-35 000 pg/ml. Groups were compared in terms of short-term all-cause mortality. Patients with higher NT-proBNP had worst GRS on admission. They also received less aggressive treatment. In-hospital mortality was 0.8%, 3.0%, 5.8% and 12.8% (P<0.001) and 30-day mortality 1.6%, 4.6%, 6.5% and 16.7% (P<0.001) respectively. In multivariate logistic regression analysis, NT-proBNP is an independent predictor of in-hospital (OR 2.35; 95% CI: 1.12-4.93, P=0.022) and 30-day mortality (OR 2.20; 95% CI: 1.17-4.12, P=0.014). However, NT-proBNP does not add any incremental benefit to GRS for prediction of outcome by ROC curve analysis. CONCLUSIONS: NT-proBNP is an independent predictor of in-hospital and 30-day mortality after ACS, independently of left ventricular function, but does not increase the prognostic accuracy of GRS.
Peer review: yes
URI: http://hdl.handle.net/10400.17/2672
DOI: 10.1080/17482940903177036
Aparece nas colecções:CAR - Artigos
PAT CLIN - Artigos

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