Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2297
Título: Lack of Spontaneous Venous Pulsation: Possible Risk Indicator in Normal Tension Glaucoma?
Autor: Abegão Pinto, L
Vandewalle, E
De Clerck, E
Marques-Neves, C
Stalmans, I
Palavras-chave: CHLC OFT
Blood Flow Velocity/physiology
Blood Pressure/physiology
Glaucoma, Open-Angle/physiopathology
Intraocular Pressure/physiology
Low Tension Glaucoma/physiopathology
Orbit/blood supply
Regional Blood Flow/physiology
Retinal Vein/physiopathology
Risk Factors
Tonometry, Ocular
Ultrasonography, Doppler, Color
Visual Acuity/physiology
Visual Fields
Glaucoma, Primary Open Angle
Data: 2013
Editora: Wiley
Citação: Acta Ophthalmol. 2013 Sep;91(6):514-20
Resumo: PURPOSE: Recently, the absence of spontaneous venous pulsation (SVP) has been suggested as a vascular risk factor for primary open-angle glaucoma (POAG). As the mechanism behind this phenomenon is still unknown, the authors have studied this vascular component using colour Doppler imaging (CDI). METHODS: A total of 236 patients were divided into three diagnostic groups: healthy controls (81), POAG (86) and normal tension glaucoma (NTG; 69). All subjects were submitted to CDI studies of the retrobulbar circulation, intraocular pressure measurements and assessment of SVP existence. Mann-Whitney, chi-square contingency tables and Spearman correlations were used to explore differences and correlations between variables in the diagnostic groups. RESULTS: Eighty-two percent of healthy controls had SVP (66/81), while a smaller numbers were registered in both glaucoma groups: POAG - 50% (43/86); NTG - 51% (35/69). In NTG patients, but not in POAG patients, the prevalence of the SVP phenomenon decreases with increased glaucoma damage (p = 0.04; p = 0.55, respectively). Overall glaucoma patients from both groups had lower central retinal vein (CRV) velocities than the healthy controls (p < 0.05). NTG patients with SVP had less severe visual field defects (mean defect -6.92 versus -11.1, p < 0.05), higher [correction added after online publication 21 September 2012; the word 'higher' has been inserted to replace the word 'lower'] peak systolic and mean flow velocities in the central retinal artery (p < 0.01; p < 0.05, respectively) as well as higher [correction added after online publication 21 September 2012; the word higher has been inserted to replace the word lower] maximal velocities and RI of the CRV (p < 0.02; p < 0.05, respectively). CONCLUSIONS: Glaucoma patients have a decrease in CRV velocities. SVP is less prevalent in glaucoma patients than in healthy individuals. This phenomenon apparently reflects different hemodynamic patterns in the central retinal vessels. This variable may be of particular importance in NTG patients, where it may be associated with more advanced functional damage.
Peer review: yes
URI: http://hdl.handle.net/10400.17/2297
DOI: 10.1111/j.1755-3768.2012.02472.x
Aparece nas colecções:OFT - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Acta Ophthalmol 2013 514.pdf184,23 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.