Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2293
Título: Liver Depurative Techniques: A Single Liver Transplantation Center Experience
Autor: Rodrigues, J
Castro, S
Moya, B
Fortuna, P
Martins, A
Pereira, JP
Bento, L
Perdigoto, R
Barroso, E
Marcelino, P
Palavras-chave: End Stage Liver Disease/mortality
End Stage Liver Disease/surgery
Follow-Up Studies
Liver Failure, Acute/mortality
Liver Failure, Acute/surgery
Liver Transplantation/methods
Liver Transplantation/mortality
Retrospective Studies
Survival Rate/trends
Time Factors
Data: 2015
Editora: Elsevier
Citação: Transplant Proc. 2015 May;47(4):996-1000
Resumo: In a liver transplant (LT) center, treatments with Prometheus were evaluated. The main outcome considered was 1 and 6 months survival. Methods. During the study period, 74 patients underwent treatment with Prometheus; 64 were enrolled,with a mean age of 51 13 years; 47men underwent 212 treatments (mean, 3.02 per patient). The parameters evaluated were age, sex, laboratorial (liver enzymes, ammonia) and clinical (model for end-stage liver disease and Child-Turcotte-Pugh score) data. Results. Death was verified in 23 patients (35.9%) during the hospitalization period, 20 patients (31.3%) were submitted to liver transplantation, and 21 were discharged. LT was performed in 4 patients with acute liver failure (ALF, 23.7%), in 7 patients with acute on chronic liver failure (AoCLF, 43.7%), and in 6 patients with liver disease after LT (30%). Seven patients who underwent LT died (35%). In the multivariate analysis, older age (P ¼ .015), higher international normalized ratio (INR) (P ¼ .019), and acute liver failure (P ¼ .039) were independently associated with an adverse 1-month clinical outcome. On the other hand, older age (P ¼ .011) and acute kidney injury (P ¼ .031) at presentation were both related to worse 6-month outcome. For patients with ALF and AoCLF we did not observe the same differences. Conclusions. In this cohort, older age was the most important parameter defining 1- and 6-month survival, although higher INR and presence of ALF were important for 1-month survival and AKI for 6-month survival. No difference was observed between patients who underwent LT or did not have LT.
Peer review: yes
URI: http://hdl.handle.net/10400.17/2293
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