Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2292
Título: Clinical Outcomes and Genetic Expression Profile in Human Liver Graft Dysfunction During Ischemia/Reperfusion Injury
Autor: Paulino, J
Vigia, E
Marcelino, P
Abade, O
Sobral, J
Ligeiro, D
Carvalho, A
Alves, M
Papoila, AL
Trindade, H
Barroso, E
Palavras-chave: Cold Ischemia/methods
HCC ANPAT
HCC CHBPT
Gene Expression Profiling/methods
Gene Expression Regulation
Genetic Markers/genetics
Liver Diseases/genetics
Liver Diseases/metabolism
Liver Diseases/surgery
Liver Transplantation
Microarray Analysis
RNA/genetics
Reperfusion Injury/genetics
Reperfusion Injury/metabolism
Retrospective Studies
Transplants/metabolism
Transplants/pathology
Data: 2015
Editora: Elsevier
Citação: Transplant Proc. 2015 May;47(4):882-7
Resumo: Introduction. This study aims to compare the molecular gene expression during ischemia reperfusion injury. Several surgical times were considered: in the beginning of the harvesting (T0), at the end of the cold ischemia period (T1), and after reperfusion (T2) and compared with graft dysfunction after liver transplant (OLT). Methods. We studied 54 patients undergoing OLT. Clinical, laboratory data, and histologic data (Suzuki classification) as well as the Survival Outcomes Following Liver Transplantation (SOFT) score were used and compared with the molecular gene expression of the following genes: Interleukin (IL)-1b, IL-6, tumor necrosis factor-a, perforin, E-selectin (SELE), Fas-ligand, granzyme B, heme oxygenase-1, and nitric oxide synthetase. Results. Fifteen patients presented with graft dysfunction according to SOFT criteria. No relevant data were obtained by comparing the variables graft dysfunction and histologic variables. We observed a statistically significant relation between SELE at T0 (P ¼ .013) and IL-1b at T0 (P ¼ .028) and early graft dysfunction. Conclusions. We conclude that several genetically determined proinflammatory expressions may play a critical role in the development of graft dysfunction after OLT.
Peer review: yes
URI: http://hdl.handle.net/10400.17/2292
Aparece nas colecções:ANPAT - Artigos
CHBPT - Artigos

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