Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2228
Título: Neuromyelitis Optica in Portugal (NEMIPORT) - A Multicentre Study
Autor: Domingos, J
Isidoro, L
Figueiredo, R
Brum, M
Capela, C
Barros, P
Santos, E
Macário, MC
Pinto Marques, J
Pedrosa, R
Vale, J
Sá, MJ
Palavras-chave: HSAC OFT
Age of Onset
Aquaporin 4/immunology
Autoimmune Diseases/epidemiology
Autoimmune Diseases/immunology
Cohort Studies
Follow-Up Studies
Immunoglobulin G/immunology
Magnetic Resonance Imaging
Neuromyelitis Optica/epidemiology
Neuromyelitis Optica/immunology
Neuromyelitis Optica/pathology
Optic Neuritis/epidemiology
Optic Neuritis/immunology
Optic Neuritis/pathology
Retrospective Studies
Sex Distribution
Data: 2015
Editora: Elsevier
Citação: Clin Neurol Neurosurg. 2015 Jul;134:79-84
Resumo: BACKGROUND: Neuromyelitis Optica (NMO) is an inflammatory demyelinating disease of the CNS. There have been few epidemiologic studies on NMO, none in Portugal. OBJECTIVE: To analyze the clinical, biological and MRI characteristics from a cohort of Portuguese patients who fulfilled the Wingerchuk 2006 NMO/NMOSD criteria. To identify and characterize those who had concomitant autoimmune disease or circulating autoantibodies. METHODS: We performed an observational, retrospective, multicenter study in 5 Hospital Centers in Portugal. RESULTS: Sixty-seven patients fulfilled the inclusion criteria. They were mainly Caucasian, 55 female. Median age at onset was 32.0 years and mean follow-up 7.4±6.0 years. Twenty-one patients were definite NMO and optic neuritis (ON) the most frequent initial presentation. Forty-six were classified as NMO spectrum disorders. The main subtypes were recurrent ON and single longitudinally extensive transverse myelitis. Twenty-four patients had positive AQP4-IgG. Twenty-three had other circulating autoantibodies. Fifteen out of 67 patients had concomitant autoimmune disease. There was a significant correlation between the presence of autoimmune disease and the positivity for AQP4-IgG. Five patients died, all definite NMO. CONCLUSION: This is the first study about this rare disease in Portugal. Demographic features were similar to other studies. The existence of concomitant autoimmune disease was significantly associated with seropositivity for AQP4-IgG.
Peer review: yes
URI: http://hdl.handle.net/10400.17/2228
Aparece nas colecções:NEU - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
CNN 2015.pdf379,79 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.