Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2140
Título: Idiopathic Hypocomplementaemic Tubulointerstitial Nephritis
Outros títulos: Nefrite Túbulo-Intersticial Hipocomplementémica Idiopática
Autor: Azevedo, A
Mesquita, I
Viana, H
Rocha, G
Ferreira, C
Fernandes, V
Murinello, A
Carvalho, F
Nolasco, F
Palavras-chave: HCC NEF
HCC MED
Renal Failure, Chronic
Nephritis, Tubulointerstitial
Data: 2015
Editora: Sociedade Portuguesa de Nefrologia
Citação: Port J Nephrol Hypert 2015; 29 (1): 71-77
Resumo: Background: Tubulointerstitial nephritis (TIN) is a common cause of kidney injury typically seen in association with drug exposure, infection or autoimmune diseases. However, TIN with interstitial immune complex deposition, without glomerular injury, is rarely observed. Case: We report a case of a 64-yearold Indian woman admitted for dialysis-requiring renal failure, without involvement of other organs. Urinalysis showed blood 3+ and 24h proteinuria of 1.5 g. Renal ultrasound revealed normal sized kidneys with loss of parenchymal-sinus differentiation. Laboratory tests disclosed low C3, positive ANA but negative anti-dsDNA, SSA and SSB. Serum protein electrophoresis was normal. The renal biopsy showed tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane with glomerular sparing. The patient started prednisolone (1mg/kg/day) without recovery of the renal function. Conclusion: Idiopathic hypocomplementaemic tubulointerstitial nephritis is a rare disease with few cases described in the literature. To our knowledge this is the first case reported in Portugal.
Peer review: yes
URI: http://hdl.handle.net/10400.17/2140
Aparece nas colecções:MED - Artigos
NEF - Artigos

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