Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/2132
Título: Health-Related Quality of Life Impact of a Triple Combination of Olmesartan Medoxomil, Amlodipine Besylate and Hydrochlorotiazide in Subjects with Hypertension
Autor: Marques da Silva, P
Haag, U
Guest, J
Brazier, J
Soro, M
Palavras-chave: HSM MED
Amlodipine/administration & dosage
Analysis of Variance
Antihypertensive Agents/administration & dosage
Drug Combinations
Hydrochlorothiazide/administration & dosage
Hypertension/drug therapy
Imidazoles/administration & dosage
Quality of Life/psychology
Tetrazoles/administration & dosage
Treatment Outcome
Data: 2015
Editora: BioMed Central
Citação: Health Qual Life Outcomes. 2015 Feb 21;13(1):24
Resumo: BACKGROUND: A post-hoc analysis was performed on the data from a 54 weeks phase III study (ClinicalTrials.gov identifier: NCT00923091) to measure changes in the health-related quality of life (HRQoL) of 2,690 patients aged ≥18 with moderate-to-severe hypertension who received one of six doses of olmesartan/amlodipine/hydrochlorothiazide (OLM/AML/HCTZ), using the MINICHAL and EQ-5D instruments. METHODS: Descriptive statistics were used to assess blood pressure and HRQoL scores over the study period. Analysis of covariance (ANCOVA) was used to identify those factors that could possibly have influenced HRQoL. Linear regression was used to assess the relationship between changes in blood pressure and HRQoL scores. RESULTS: Patients' baseline MINICHAL mood and somatic domains scores were 5.5 and 2.6. Over the study period HRQoL improved as both MINICHAL scores decreased by 31-33%. Patients' baseline EQ-5D index and VAS scores were 0.9 and 73.4 respectively, increasing by 6% and 12% over the study period. Patients' QALY gain over the 54 weeks study period was estimated to be 0.029 QALYs. The ANCOVA showed that changes in patients' HRQoL was likely to have been influenced by patients' achievement of blood pressure control, the amount of concomitant medication and patients' last used dosage strength of antihypertensive. Linear regression showed that blood pressure improvement may have been associated with improved HRQoL. CONCLUSIONS: This study showed that OLM/AML/HCTZ reduced blood pressure and significantly increased blood pressure control whilst improving patients' HRQoL. Achieving blood pressure control, amount of concomitant medication and dosage strength of antihypertensive impacted on patients' HRQoL.
Peer review: yes
URI: http://hdl.handle.net/10400.17/2132
Aparece nas colecções:MED - Artigos

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