Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1898
Título: Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention
Autor: Ramos, C
Napoleão, P
Selas, M
Freixo, C
Viegas Crespo, AM
Mota Carmo, M
Cruz Ferreira, R
Pinheiro, T
Palavras-chave: HSM CAR
Biological Markers/blood
Case-Control Studies
Coronary Artery Disease/blood
Coronary Artery Disease/therapy
Percutaneous Coronary Intervention
Vascular Endothelial Growth Factor A/blood
Data: 2014
Editora: Hindawi Publishing Corporation
Citação: Dis Markers. 2014;2014:135357
Resumo: We examined the longitudinal changes of VEGF levels after percutaneous coronary intervention for predicting major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. VEGF was measured in 94 CAD patients' serum before revascularization, 1-month and 1-year after. Independently of clinical presentation, patients had lower VEGF concentration than a cohort of healthy subjects (median, IQ: 15.9, 9.0-264 pg/mL versus 419, 212-758 pg/mL; P < 0.001) at baseline. VEGF increased to 1-month (median, IQ: 276, 167-498 pg/mL; P < 0.001) and remained steady to 1-year (median, IQ: 320, 173-497 pg/mL; P < 0.001) approaching control levels. Drug eluting stent apposition and previous medication intake produced a less steep VEGF evolution after intervention (P < 0.05). Baseline VEGF concentration <40.8 pg/mL conveyed increased risk for MACE in a 5-year follow-up. Results reflect a positive role of VEGF in recovery and support its importance in CAD prognosis.
Peer review: yes
URI: http://hdl.handle.net/10400.17/1898
DOI: 10.1155/2014/135357
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