Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1803
Título: Brain Natriuretic Peptide Levels Predict Morbidity and Mortality in Haemodialysis Patients
Autor: Matias, P
Jorge, C
Aires, I
Lage, H
Gil, C
Gomes, F
Arranhado, E
Ferreira, A
Palavras-chave: HCC NEF
Peptídeo Natriurético Encefálico
Mortalidade
Hemodiálise
Data: 2009
Editora: Sociedade Portuguesa de Nefrologia
Citação: Port J Nephrol Hypert 2009; 23(3): 249-255
Resumo: Background: Brain natriuretic peptide is a predictor of mortality in multiple cardiovascular diseases but its value in patients with chronic kidney disease is still a matter of debate. Patients and methods: We studied 48 haemodialysis patients with mean age 70.0±13.9 years,62.5% female, 43.8% diabetics, with a mean haemodialysis time of 38.1±29.3 months. To evaluate the role of brain natriuretic peptide as a prognostic factor in this population we performed a two-session evaluation of pre- and postmid-week haemodialysis plasma brain natriuretic peptide concentrations and correlated them with hospitalisation and overall and cardiovascular mortality over a two-year period. Results: There were no significant variations in pre– and post-haemodialysis plasma brain natriuretic peptide concentrations. Pre- and post-haemodialysis brain natriuretic peptide concentrations were significantly greater in patients who died from all causes(p=0.034 and p=0.001, respectively) and from cardiovascular causes (p=0.043 and p=0.001, respectively). Patients who were hospitalised in the two-year study period also presented greater pre- and posthaemodialysis brain natriuretic peptide concentrations(p=0.03 and p=0.036, respectively). Patients with mean brain natriuretic peptide concentrations ≥ 390 pg/mL showed a significantly lower survival at the end of the two-year study period. Conclusion: Brain natriuretic peptide was a good predictor of morbidity and mortality (overall and cardiovascular) in our population.
Peer review: yes
URI: http://hdl.handle.net/10400.17/1803
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