Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1771
Título: HIV-2 Integrase Polymorphisms and Longitudinal Genotypic Analysis of HIV-2 Infected Patients Failing a Raltegravir-Containing Regimen
Autor: Cavaco-Silva, J
Abecasis, A
Miranda, AC
Poças, J
Narciso, J
Águas, MJ
Maltez, F
Almeida, I
Germano, I
Diniz, A
Gonçalves, MF
Gomes, P
Cunha, C
Camacho, RJ
Palavras-chave: HCC INF
Drug Resistance, Viral/genetics
Genotype
HIV Infections/drug therapy
HIV Integrase/genetics
HIV Integrase Inhibitors/therapeutic use
HIV-1/drug effects
HIV-2/drug effects
HIV-2/genetics
Polymorphism, Genetic/genetics
Pyrrolidinones/therapeutic use
Data: 2014
Editora: PLOS One
Citação: PLoS One. 2014 Mar 28;9(3):e92747
Resumo: To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase residues were conserved, including the catalytic motif residues. No INSTI-major resistance mutations were detected in the virus population from naïve patients, but two amino acids that are secondary resistance mutations to INSTIs in HIV-1 were observed. The 10 raltegravir-experienced patients exhibited resistance mutations via three main genetic pathways: N155H, Q148R, and eventually E92Q - T97A. The 155 pathway was preferentially used (7/10 patients). Other mutations associated to raltegravir resistance in HIV-1 were also observed in our HIV-2 population (V151I and D232N), along with several novel mutations previously unreported. Data retrieved from this study should help build a more robust HIV-2-specific algorithm for the genotypic interpretation of raltegravir resistance, and contribute to improve the clinical monitoring of HIV-2-infected patients.
Peer review: yes
URI: http://hdl.handle.net/10400.17/1771
Aparece nas colecções:INF - Artigos

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