Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1699
Título: Budesonide Reverses Lung Hyperinflation in Childhood Asthma: a Controlled Study
Autor: Neuparth, N
Gamboa, T
Pereira, C
Rosado-Pinto, J
Rendas, A
Palavras-chave: Asma
Broncopatias
Budesonida
Criança
HDE ALER
Data: 1999
Editora: Elsevier
Citação: Pathophysiology. 1999; 6:199–204
Resumo: Budesonide (800 mg bid, for 2 months) was administered to 12 asthmatic children (mean age, 11.293.3 years) with lung hyperinflation (TGV]130% predicted and:or RV]140% predicted) in a randomised, placebo controlled, double blind, crossover study. Body plethysmography (panting frequency controlled at 1·s 1) was performed at the beginning, 2 months afterwards (before crossover) and at the end of the study. Budesonide significantly reduced TGV (2.3590.90 l BTPS or 126924% predicted) compared with placebo (2.5491.08 l BTPS, P 0.014 or 140921% predicted, PB0.05). In addition, budesonide significantly increased mean specific conductance (0.0690.02 cm H2O 1 l s 1 to 0.0790.01 cm H2O 1 l s 1, PB0.05). It was concluded that budesonide reduced lung hyperinflation most likely by decreasing airway inflammation.
URI: http://hdl.handle.net/10400.17/1699
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