Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1680
Título: Breast Cancer Presents With a Paraneoplastic Neurologic Syndrome
Autor: Coelho Barata, P
Morgado, J
Sousa, AP
Duarte de Oliveira, S
Custódio, MP
Bruno da Costa, L
Esteves Pena, J
Palavras-chave: CHLC NEU
CHLC ONC
Breast Cancer
Paraneoplastic Neurologic Syndromes
Onconeural Antibodies
Data: 2012
Editora: Karger
Citação: Case Rep Oncol. 2012 Sep;5(3):616-21
Resumo: BACKGROUND: Paraneoplastic neurologic syndromes (PNS) pose quite an uncommon neurological complication, affecting less than 1% of patients with breast cancer. Nearly one third of these patients lack detectable onconeural antibodies (ONAs), and improvement in neurologic deficits with concomitant cancer treatments is achieved in less than 30% of cases. CASE PRESENTATION: A 42-year-old, premenopausal woman presented with facial paralysis on the central left side accompanied by a left tongue deviation, an upward vertical nystagmus, moderate spastic paraparesis, dystonic posturing of the left foot, lower limb hyperreflexia and bilateral extensor plantar reflex. After ruling out all other potential neurologic causes, PNS was suspected but no ONAs were found. A PET-CT scan detected increased metabolism in the right breast, as well as an ipsilateral thoracic interpectoral adenopathy. Core biopsy confirmed the presence of an infiltrating duct carcinoma. After breast surgery, the neurologic symptoms disappeared. One week later, the patient was readmitted to the hospital with a bilateral fatigable eyelid ptosis, and two weeks later, there was a noticeable improvement in eyelid ptosis, accompanied by a rapid and progressive development of lower spastic paraparesis. She started adjuvant treatment with chemotherapy with marked clinical and neurological improvement, and by the end of radiotherapy, there were no signs of neurologic impairment. CONCLUSION: This case study highlights the importance of a high level of vigilance for the detection of PNS, even when ONAs are not detected, as the rapid identification and treatment of the underlying tumor offers the best chance for a full recovery.
Peer review: yes
URI: http://hdl.handle.net/10400.17/1680
Aparece nas colecções:NEU - Artigos
ONC - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Case Rep Oncol 2012.pdf665,31 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.