Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1669
Título: Spectrum of Neurologic Complications in Chronic Lymphocytic Leukemia
Autor: Lopes Silva, R
Palavras-chave: Sistema Nervoso Central
Leucemia Linfocítica Crônica de Células B
Sistema Nervoso Periférico
Data: 2012
Editora: Elsevier
Citação: Clin Lymph Myelom Leukem. 2012; 12(3): 164-79
Resumo: Neurologic disease is believed to be an unusual complication during the course of chronic lymphocytic leukemia. Nevertheless, it has already been proven in autopsy series that the incidence of occult nervous system infiltration is much higher than was previously expected. The advent of more potent drugs to treat this lymphoproliferative disorder has brought a new hope for a possible cure in the future. However, an appropriate systemic treatment for central nervous system infiltration of this disease is still lacking. Also, due to the potent immunosuppressive properties of the agents used in the up-front treatment, for example, the purine nucleoside analogues, we have witnessed an increase in the incidence of opportunistic infections, with progressive multifocal leukoencephalopathy being one of the most serious. The goal of this review is to summarize the spectrum of neurologic derangements linked to chronic lymphocytic leukemia and to raise clinicians’ awareness to recognize the possibility of such associations.
URI: http://hdl.handle.net/10400.17/1669
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