Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1656
Título: Conservative Treatment of Chondrodermatitis Nodularis Chronica Helicis with Topical Nitroglycerin
Autor: Cabete, J
Lencastre, A
Paiva Lopes, MJ
Lestre, S
Serrão, V
Palavras-chave: HSAC DER
Doenças da Pele
Data: 2013
Editora: Serviço de Dermatologia do Hospital dos Capuchos, Centro Hospitalar de Lisboa Central, EPE
Citação: IN: 71st Annual Meeting of the American Academy of Dermatology; 2013, Março. Miami, EUA
Resumo: Background: Chondrodermatitis nodularis chronica helicis (CNCH) is a benign, painful, indurated inflammatory nodule arising on the pinna. Different treatment modalities have been used with varying efficacy rates. Despite lower efficacy, conservative methods are most desirable. Case reports: Three patients diagnosed with CNCH were treated with 0.4% topical nitroglycerin ointment, twice daily. These included two women and one man, aged 66, 86, and 60-years-old, respectively. Two painful nodules were located on the antihelix, and one on the helix. One patient had been previously treated with intralesional corticosteroids, and another with intralesional corticosteroids, CO2 laser and photodynamic therapy. All three patients experienced significant clinical and symptomatic improvement with topical nitroglycerin. No side effects were reported. Discussion: The etiology of CNCH is uncertain. Dermal and chondral ischemia arising from perichondrial arterial narrowing has been recently described as a possible cause for this benign condition, hence the potential of nitroglycerin as a smooth muscle relaxant and vasodilator. A previous report described significant improvement in twelve patients treated with 2% topical nitroglycerin. Conclusion: Topical nitroglycerin ointment appears to be a noninvasive alternative for the treatment of CNCH. A lower concentration (0.4%) may be as effective and with fewer side effects, but more studies are warranted.
URI: http://hdl.handle.net/10400.17/1656
Aparece nas colecções:DER - Comunicações e Conferências

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