Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1608
Título: Infliximab in Recalcitrant Generalized Pustular Arthropatic Psoriasis
Autor: Serrão, V
Martins, A
Paiva Lopes, MJ
Palavras-chave: HSAC DER
Anticorpos Monoclonais
Artrite Psoriática
Factor de Necrose Tumoral Alfa
Terapêutica
Data: 2008
Editora: John Libbey Eurotext
Citação: Eur J Dermatol. 2008 Jan-Feb;18(1):71-3
Resumo: Generalized pustular psoriasis is an unstable inflammatory type of psoriasis, with widespread areas of erythema and sterile pustules, associated with fever and systemic symptoms. Infliximab is a monoclonal antibody with anti-TNFalpha activity, approved for use in psoriasis. We describe a male patient with a long history of stable arthropathic psoriasis, hospitalized with a generalized pustular psoriasis and acute exacerbation of articular complaints. The disease was resistant to multiple therapies (acitretin, methotrexate and corticosteroids), so the patient was started on infliximab, with a very rapid response of both cutaneous and articular symptoms. He had complete clearing of lesions at week 12, and marked improvement of the articular symptoms. No recurrence occurred at 8 months of follow-up with infliximab every 8 weeks. Infliximab had an extremely rapid therapeutic action response on a recalcitrant generalized pustular psoriasis. The articular response was also excellent, with significant improvement of quality of life.
Peer review: yes
URI: http://hdl.handle.net/10400.17/1608
Aparece nas colecções:DER - Artigos

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