Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1466
Título: Transplant Glomerulopathy: Clinico-Pathologic Features
Outros títulos: Glomerulopatia do Transplante: Análise Clínico-Patológica
Autor: Silva, C
Cotovio, P
Marques, M
Afonso, N
Sancho, MR
Carvalho, F
Trindade, H
Carreira, A
Campos, M
Nolasco, F
Palavras-chave: Anticorpos
Histologia
Rim
Transplantação de Rim
Estudos Retrospectivos
Data: 2013
Editora: Sociedade Portuguesa de Nefrologia
Citação: Port J Nephrol Hypert 2013; 27 (3): 209-215
Resumo: Transplant glomerulopathy is a sign of chronic kidney allograft damage. It has a distinct morphology and is associated with poor allograft survival. We aimed to assess the prevalence and clinic-pathologic features of transplant glomerulopathy, as well as determine the functional and histological implications of its severity. We performed a single-centre retrospective observational study during an eight-year period. Kidney allograft biopsies were diagnosed and scored according to the Banff classification, coupled with immunofluorescence studies. The epidemiology, clinical presentation, outcomes (patient and graft survival) and anti-HLA alloantibodies were evaluated. Transplant glomerulopathy was diagnosed in 60 kidney transplant biopsies performed for clinical reasons in 49 patients with ABO compatible renal transplant and a negative T-cell complement dependent cytotoxicity crossmatch at transplantation. The estimated prevalence of transplant glomerulopathy was 7.4% and its cumulative prevalence increased over time. C4d staining in peritubular capillaries (27.6%) was lower than the frequency of anti-HLA antibodies (72.5%), the majority against both classes I and II. Transplant glomerulopathy was associated with both acute (mainly glomerulitis and peritubular capillaritis) and chronic histologic abnormalities. At diagnosis, 30% had mild, 23.3% moderate and 46.7% severe transplant glomerulopathy. The severity of transplant glomerulopathy was associated with the severity of interstitial fibrosis. Other histological features, as well as clinical manifestations and graft survival, were unrelated to transplant glomerulopathy severity.
Peer review: yes
URI: http://hdl.handle.net/10400.17/1466
Aparece nas colecções:NEF - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
RPNH 2013 209.pdf500,3 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.