Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/139
Título: Da Disfunção Endotelial à Oclusão Vascular Papel do Sistema Renina - Angiotensina
Outros títulos: From Endothelial Dysfunction to Vascular Occlusion: Role of the Renin-Angiotensin System
Autor: Marques da Silva, P
Palavras-chave: Sistema Renina-Angiotensina
Angiotensina II
Apoptose
Coagulação Sanguínea
Doenças Cardiovasculares
Fibrinólise
Músculo Liso Vascular
Receptores de Angiotensina
Data: 2010
Editora: Sociedade Portuguesa de Cardiologia
Citação: Rev Port Cardiol 2010: 29 (5): 801-824
Resumo: There is a body of evidence that supports the important role of the renin-angiotensin system (RAS) in atherosclerotic disease and in the cardiovascular disease continuum: from endothelial dysfunction to vascular occlusion. In the earlier stages of vascular disease, the RAS promotes functional changes, of which endothelial dysfunction is the best example. The deposition of atherogenic lipoproteins in the intima, their oxidative modification and the onset and amplification of the inflammatory response strengthens the atherogenic role of the RAS. Inflammatory cells are one of the main sources of angiotensin-converting enzyme (ACE) and angiotensin II (Ang II) in the vascular wall, in a process that leads to structural changes in the artery and progression of atherosclerotic disease. Ang II promotes the migration of vascular smooth muscle cells and their phenotypic differentiation in synthesis that accelerates vascular disease. By modulating the inflammatory response and, in general, all the elements of the plaque, Ang II plays a part in its instability, in the onset of acute events and in the promotion of the local prothrombotic state that leads to infarction.
URI: http://hdl.handle.net/10400.17/139
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