Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1298
Título: Continuous Infusion of Piperacillin/Tazobactam in Septic Critically Ill Patients - a Multicenter Propensity Matched Analysis
Autor: Gonçalves-Pereira, J
Serra Oliveira, B
Janeiro, S
Estilita, J
Monteiro, C
Salgueiro, A
Vieira, A
Gouveia, J
Paulino, C
Bento, L
Póvoa, P
Palavras-chave: Agentes Anti-Bacterianos
Terapêutica e Dosagem
Bactérias
Efeitos Terapêuticos
Estado Terminal
Infecção
Unidades de Cuidados Intensivos
Ácido Penicilânico
Isolamento e Purificação
Piperacilina
Portugal
Mortalidade
Terapêutica
Data: 2012
Editora: Plos One
Citação: PLoS One. 2012;7(11):e49845
Resumo: The clinical efficacy of continuous infusion of piperacillin/tazobactam in critically ill patients with microbiologically documented infections is currently unknown. We conducted a retrospective multicenter cohort study in 7 Portuguese intensive care units (ICU). We included 569 critically ill adult patients with a documented infection and treated with piperacillin/tazobactam admitted to one of the participating ICU between 2006 and 2010. We successfully matched 173 pairs of patients according to whether they received continuous or conventional intermittent dosing of piperacillin/tazobactam, using a propensity score to adjust for confounding variables. The majority of patients received 16g/day of piperacillin plus 2g/day of tazobactam. The 28-day mortality rate was 28.3% in both groups (p = 1.0). The ICU and in-hospital mortality were also similar either in those receiving continuous infusion or intermittent dosing (23.7% vs. 20.2%, p = 0.512 and 41.6% vs. 40.5%, p = 0.913, respectively). In the subgroup of patients with a Simplified Acute Physiology Score (SAPS) II>42, the 28-day mortality rate was lower in the continuous infusion group (31.4% vs. 35.2%) although not reaching significance (p = 0.66). We concluded that the clinical efficacy of piperacillin/tazobactam in this heterogeneous group of critically ill patients infected with susceptible bacteria was independent of its mode of administration, either continuous infusion or intermittent dosing.
Peer review: yes
URI: http://hdl.handle.net/10400.17/1298
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