Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1016
Título: The 2009 Pandemic Influenza A (H1N1) Infection: Renal Histopathology Findings in Two Infected Patients
Autor: Fernandes, V
Ferreira, AC
Viana, H
Carvalho, F
Vila Lobos, A
Nolasco, F
Palavras-chave: Lesão Renal Aguda
Vírus da Gripe A, Subtipo H1N1
Necrose Tubular Aguda
Data: 2011
Editora: Sociedade Portuguesa de Nefrologia e Hipertensão
Citação: Port J Nephrol Hypert 2011; 25 (4): 291-294
Resumo: Background: Acute kidney injury in the pandemic swine origin influenza A virus (H1N1) infection has been reported as coursing with severe illness, although renal pathogenic mechanisms and histologic features are still being characterised. Case Report: We present two patients admitted with H1N1 pneumonia, sepsis, acute respiratory distress syndrome and need for invasive mechanical ventilation who developed acute kidney injury and became dialysis-dependent. In both cases a kidney biopsy was performed to establish a definitive diagnosis. Severe acute tubular necrosis was identified, with no further abnormalities. Conclusion: This report seems to confirm that the acute kidney injury in H1N1 infection is focused on the tubular cells. Our cases corroborate the renal histopathologic findings of other studies, highlighting the central role of the tubular cell. We bring new evidence of the histopathology of AKI in H1N1 infection since our data were collected in living patients and not via post-mortem studies.
Peer review: yes
URI: http://hdl.handle.net/10400.17/1016
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