Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.17/1006
Título: Borderline CD30+ Cutaneous Lymphoproliferative Disorder: Report of a Case with Expression of Cytotoxic Markers and Response to Clarithromycin
Autor: Ponte, P
Serrão, V
Viana, I
Vale, E
João, A
Cerroni, L
Palavras-chave: Anti-Inflamatórios
Antigénio CD30
Linfoma Cutâneo de Células T
Neoplasias da Pele
Marcadores Biológicos de Tumor
Data: 2011
Editora: John Wiley & Sons
Citação: J Cutan Pathol. 2011 Mar;38(3):301-5
Resumo: CD30+ cutaneous lymphoproliferative disorders (CLPDs) are usually characterized by a benign clinical course. The prognostic value of cytotoxic markers in these lymphomas has not been evaluated in large series. We describe a case of borderline CD30+ CLPD with cytotoxic phenotype, presenting in a 22-year-old male patient as an ulcer on the forearm. He reported having had similar ulcers on the buttock and thigh that spontaneously regressed over the course of 1 year. The lesion resolved with a single course of clarithromycin; a subsequent lesion, too, responded to clarithromycin, and no recurrences or systemic involvement have been documented in the 9-month follow-up. A conservative approach in the management of CD30+ CLPD is recommended. We believe that the anti-inflammatory and apoptotic effects of clarithromycin on T cells may have hastened the remission process.
Peer review: yes
URI: http://hdl.handle.net/10400.17/1006
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